Phenotypes Associated with This Genotype

Genotype
MGI:3043777

• Allelic Composition: Glra3^tm1.1Umu/Glra3^tm1.1Umu
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal nociception after inflammation ( J:89981 )

• homozygous mice do not show a decrease in paw withdrawal latency after exposure to heat or reaction scores after mechanical stimulation indicating a lack of sensitization following intrathecal injection of prostoglandin PGE₂

• after injection of zymosan A homozygous mice initially display increased sensitivity to thermal and mechanical stimulation but recover more rapidily than wild-type mice

• basal nociception, posture, activity, gait, motor coordination, and startle response are all normal in homozygous mutants

nervous system

nervous system phenotype ( J:89981 )

N • homozygous mice do not display any gross abnormalities of the brain or spinal cord