Phenotypes Associated with This Genotype

Genotype
MGI:3043177

• Allelic Composition: Robo1^tm1Matl/Robo1^tm1Matl
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal commissural neuron axon guidance ( J:89780 )

• at E11.5 misprojecting commissural axons are seen entering the doral floor plate and growing towards the ventral ventricular zone, however by E12.5 this phenotype is no longer seen

• at E12.5 many large stalled growth cones that send out multiple filopodia are seen in homozygous mutants

abnormal spinal cord lateral column morphology ( J:89780 )

• the lateral funiculus (white matter tract) is significantly thicker in homozygous mutants compared to wild-type mice as a result of commissural axons growing further away from the floor plate

cellular

abnormal commissural neuron axon guidance ( J:89780 )

• at E11.5 misprojecting commissural axons are seen entering the doral floor plate and growing towards the ventral ventricular zone, however by E12.5 this phenotype is no longer seen

• at E12.5 many large stalled growth cones that send out multiple filopodia are seen in homozygous mutants