Phenotypes Associated with This Genotype

Genotype
MGI:3039387

ht2

• Allelic Composition: Ccna1^tm1Coll/Ccna1⁺
• Genetic Background: either: 129S/SvEv or (involves: 129S/SvEv * MF1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:89030 )

♂ • significantly fewer sperm are recovered from heterozygotes compared to wild-type mice

arrest of spermatogenesis ( J:89030 )

♂ • pachytene spermatocytes are unaffected, while the number of haploid spermatids is significantly lower compared to wild-type mice

♂ • Background Sensitivity: this affect is more pronounced on an inbred 129S6/SvEvTac background than on an outbred 129S6/SvEvTac x MF1 background

reduced male fertility ( J:89030 )

♂ • the conception rate was reduced to 16% compared to 90% for wild-type mice

♂ • on an inbred 129S6/SvEv background no offspring were obtained from heterozygous matings

cellular

oligozoospermia ( J:89030 )

♂ • significantly fewer sperm are recovered from heterozygotes compared to wild-type mice