Phenotypes Associated with This Genotype

Genotype
MGI:3039386

hm1

• Allelic Composition: Ccna1^tm1Coll/Ccna1^tm1Coll
• Genetic Background: involves: 129S/SvEv * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

multinucleated giant male germ cells ( J:89030 )

♂

reproductive system

multinucleated giant male germ cells ( J:89030 )

♂

decreased testis weight ( J:89030 )

♂ • combined testes weight in homozygotes is around half that in wild-type mice even though total body weights are not significantly different

arrest of spermatogenesis ( J:89030 )

♂ • spermatozoa are absent from the vas deferens and epididymis instead the lumen of the epididymis contained many degenerating spermatocytes and some giant multi-nucleated cells

male infertility ( J:89030 )

♂

endocrine/exocrine glands

decreased testis weight ( J:89030 )

♂ • combined testes weight in homozygotes is around half that in wild-type mice even though total body weights are not significantly different