Phenotypes Associated with This Genotype

Genotype
MGI:3037939

• Allelic Composition: Tnp2^tm1Wen/Tnp2^tm1Wen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

teratozoospermia ( J:76986 )

♂

abnormal sperm head morphology ( J:76986 )

♂ • 24% of cauda epididymis spermatozoa exhibited abnormal sperm head morphology due to acrosome malformation

♂ • however, chromatin condensation in the sperm nucleus appeared normal

abnormal acrosome morphology ( J:76986 )

♂ • 30% of acrosomes in epididymal sperm appeared indented and/or partially detached from the nuclear envelope

♂ • similar abnormal acrosomes were observed in spermatids within the testis

detached acrosome ( J:76986 )

♂ • many acrosomes were not attached to the nuclear envelope

asthenozoospermia ( J:76986 )

♂ • reduced migration of sperm from the uterus to the oviduct was noted

male infertility ( J:76986 )

♂ • all homozygous males were infertile

impaired sperm penetration of zona pellucida ( J:76986 )

♂ • sperm have an impaired ability to penetrate the zona pellucida and fertilize oocytes

cellular

teratozoospermia ( J:76986 )

♂

abnormal sperm head morphology ( J:76986 )

♂ • 24% of cauda epididymis spermatozoa exhibited abnormal sperm head morphology due to acrosome malformation

♂ • however, chromatin condensation in the sperm nucleus appeared normal

abnormal acrosome morphology ( J:76986 )

♂ • 30% of acrosomes in epididymal sperm appeared indented and/or partially detached from the nuclear envelope

♂ • similar abnormal acrosomes were observed in spermatids within the testis

detached acrosome ( J:76986 )

♂ • many acrosomes were not attached to the nuclear envelope

asthenozoospermia ( J:76986 )

♂ • reduced migration of sperm from the uterus to the oviduct was noted