Phenotypes Associated with This Genotype

Genotype
MGI:3036847

• Allelic Composition: Elk4^tm1Rtr/Elk4^tm1Rtr
• Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell selection ( J:88515 )

• abnormal thymocyte selection and/or differentiation

abnormal positive T cell selection ( J:88515 )

• T cell autonomous defect affecting positive, but not negative, selection

decreased T cell number ( J:88515 )

• reduced number of peripheral T cells

decreased thymocyte number ( J:88515 )

• 50% reduction in the proportion of TCR^hi thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:88515 )

• 50% reduction in the proportion of single-positive CD4⁺thymocytes

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• reduction in the proportion of single-positive CD8⁺ thymocytes

decreased single-positive T cell number ( J:88515 )

immune system

abnormal T cell selection ( J:88515 )

• abnormal thymocyte selection and/or differentiation

abnormal positive T cell selection ( J:88515 )

• T cell autonomous defect affecting positive, but not negative, selection

decreased T cell number ( J:88515 )

• reduced number of peripheral T cells

decreased thymocyte number ( J:88515 )

• 50% reduction in the proportion of TCR^hi thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:88515 )

• 50% reduction in the proportion of single-positive CD4⁺thymocytes

decreased CD8-positive, alpha-beta T cell number ( J:88515 )

• reduction in the proportion of single-positive CD8⁺ thymocytes

decreased single-positive T cell number ( J:88515 )

endocrine/exocrine glands

decreased thymocyte number ( J:88515 )

• 50% reduction in the proportion of TCR^hi thymocytes