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Phenotypes Associated with This Genotype
Genotype
MGI:3033465
Allelic
Composition		 Hfetm1Sly/Hfetm2Sly
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm1Sly mutation (0 available); any Hfe mutation (35 available)
Hfetm2Sly mutation (0 available); any Hfe mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:88143 )
• intermediate hepatic iron concentrations
• higher than that of wild-type mice, but lower than that of Hfetm1Sly homozygotes

liver/biliary system
increased liver iron level ( J:88143 )
• intermediate hepatic iron concentrations
• higher than that of wild-type mice, but lower than that of Hfetm1Sly homozygotes

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
 J:88143

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory