Phenotypes Associated with This Genotype

Genotype
MGI:3032956

• Allelic Composition: Sema3c^tm1.1Jra/Sema3c^tm1.1Jra
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:71240 )

• mice die within 24 hours of birth due to cardiac defects

• mortality rate less than 50% on both 129 and C57BL/6 backgrounds

• mortality rate increases on CD1 background with each successive backcross

• crossing heterozygotes from the fourth CD1 backcross generation results in 96% mortality

cardiovascular system

interrupted aortic arch ( J:71240 )

• aortic arch abnormalities involving interruptions between the left common carotid and left subclavian arteries (type B) or the brachiocephalic and left common carotid arteries (type C) occurred in all mice that died perinatally

interrupted aortic arch, type b ( J:71240 )

interrupted aortic arch, type c ( J:71240 )

abnormal common carotid artery morphology ( J:71240 )

• duplication of the left common carotid is infrequently observed

common truncal valve ( J:71240 )

persistent truncus arteriosus ( J:71240 )

double outlet right ventricle ( J:71240 )

• seen in one mutant embryo

perimembraneous ventricular septal defect ( J:71240 )

• defects detected in the membranous portion of the ventricular septum but not in the muscular septum

nervous system

nervous system phenotype ( J:71240 )

N • no misprojections of the cranial nerves were detected

embryo

abnormal neural crest cell migration ( J:71240 )

• patterning of neural crest cells in the outflow tract of the heart is altered in mutant mice

• altered expression of Foxc1, endothelin receptor A, and plexinA2 suggests that neural crest cell invasion of the outflow tract is significantly impaired in mutant embryos

cellular

abnormal neural crest cell migration ( J:71240 )

• patterning of neural crest cells in the outflow tract of the heart is altered in mutant mice

• altered expression of Foxc1, endothelin receptor A, and plexinA2 suggests that neural crest cell invasion of the outflow tract is significantly impaired in mutant embryos