Phenotypes Associated with This Genotype

Genotype
MGI:3032546

• Allelic Composition: Tg^cog/Tg^cog
• Genetic Background: AKR/J-Tg^cog

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:13923 )

• obliteration of most follicular lumens

• small numbers of lymphocytes in degenerating follicles

abnormal thyroid follicular cell morphology ( J:13923 )

• hypertrophy and hyperplasia of thyrofollicular cells

enlarged thyroid gland ( J:13923 )

• reduced when diet supplemented with desiccated thyroid powder

growth/size/body

disproportionate dwarf ( J:13923 )

• evident at day 15 postnatal

• repaired when diet supplemented with desiccated thyroid powder

increased growth rate ( J:13923 )

• evident between 4 and 7 weeks of age

homeostasis/metabolism

decreased circulating thyroxine level ( J:13923 )

• serum thyroxine is significantly reduced