Analysis Tools
mortality/aging
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• as seizures and impaired coordination become more severe, the mice lose the ability to obtain food and die, usually by 4 weeks old, from starvation and thirst
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behavior/neurological
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• animals exhibited difficulty righting themselves after being placed on their backs
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endocrine/exocrine glands
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• anterior pituitary lobes were congested and hypercellular
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• the cortex appears as a mass of stromal cells and an absence of lymphocytes was noted
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• the thymic medulla is filled with cell debris and pyknotic nuclei
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• thyroid glands appear similar to controls at 11 days of age, but at 33 days of age the colloid is less homogeneous, the secreting cells are abnormally shaped and placed, and the connective tissue displays hyperplasia
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• hypoactive thyroid
• involuted thymus glands; involution is first noted coincident with the onset of impaired coordination
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immune system
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• the cortex appears as a mass of stromal cells and an absence of lymphocytes was noted
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• the thymic medulla is filled with cell debris and pyknotic nuclei
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muscle
muscle spasm
(
J:14903
)
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• severe muscle tetany was exhibited after the onset of impaired coordination
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nervous system
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• anterior pituitary lobes were congested and hypercellular
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• polycystic alterations in white matter of the brain were noted
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• degeneration of the motor neurons of the lumbar spinal cord was noted; cells appeared vacuolated
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hematopoietic system
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• the cortex appears as a mass of stromal cells and an absence of lymphocytes was noted
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• the thymic medulla is filled with cell debris and pyknotic nuclei
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