Phenotypes Associated with This Genotype

Genotype
MGI:3029453

• Allelic Composition: Ptprz1^tm1Schl/Ptprz1^tm1Schl
• Genetic Background: involves: 129 * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal oligodendrocyte morphology ( J:79860 )

• an increased incidence of apoptosis of mature oligodendrocytes was observed in EAE

abnormal myelination ( J:79860 )

• in experimental autoimmune encephalitis (EAE), mutant mice exhibit an impaired ability to recover from demyelinating lesions

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:79860 )

cellular

abnormal oligodendrocyte morphology ( J:79860 )

• an increased incidence of apoptosis of mature oligodendrocytes was observed in EAE