Phenotypes Associated with This Genotype

Genotype
MGI:2676352

• Allelic Composition: Bmp4^tm1Blh/Bmp4^tm1Blh
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal mesoderm development ( J:79391 )

• a mass of mesodermal cells extending to the apical surface of the ectoderm fills much of the posterior amniotic cavity

abnormal lateral plate mesoderm morphology ( J:79391 )

• at the 2 to 8 somite stage, over 75% of embryos show patch or reduced Nodal expression and lack expression in the left lateral plate mesoderm

• in about 65% of embryos at the 3 to 4 somite stage Lefty2 expression is absent from the lateral plate mesoderm

abnormal posterior primitive streak morphology ( J:79391 )

• an abnormal posterior bulge is present from the headfold to 6 somite stage

abnormal primitive node morphology ( J:79391 )

• node is either flat or slightly convex with an irregular periphery in embryos from the headfold to 6 somite stage unlike in controls where it is concave

• one embryo had large endoderm-like cells within the node

abnormal amniotic cavity morphology ( J:79391 )

• much of the posterior amniotic cavity is filled up by a mass of mesodermal cells that extends to the apical surface of the ectoderm

cardiovascular system

abnormal heart looping ( J:79391 )

• at the 9 to 10 somite stage in about 50% of embryos the heart tube lies centrally along the midline and shows no signs of looping