Phenotypes Associated with This Genotype

Genotype
MGI:2662524

• Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

absent megakaryocytes ( J:32131 )

• mutant mice displayed a loss of megakaryocytes in the spleen and bone marrow

abnormal megakaryocyte progenitor cell morphology ( J:32131 )

• mice are deficient in megakaryocyte progenitor cells

thrombocytopenia ( J:32131 )

• mice had only 6% the number platelets detected in controls

decreased hematopoietic stem cell number ( J:32131 )

• in clonal culture of bone marrow, total progenotor cell number was 38%- 44% of wildtype

• neutrophil-CFC, neutrophil-macrophage-CFC and pure erythroid-CFC were present at approximately 50% of normal levels

• cell reduction not seen in mature cell populations

immune system

immune system phenotype ( J:32131 )

N • no alterations were detected in the ratios of B and T cells examined in the spleen, thymus and bone marrow using momoclonal antibodies