Phenotypes for Hfe MGI:2655512 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hfe^tm1.1Nca/Hfe^tm1.1Nca
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm1.1Nca mutation (1 available); any Hfe mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal iron level ( J:78536 )

• Background Sensitivity: iron loading occurred more rapidly on a 129S6/SvEvTac background than on a mixed background

• less iron accumulation than in Hfe^tm2Nca homozygous mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemochromatosis type 1		DOID:0111029	OMIM:235200	J:78536

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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