Phenotypes Associated with This Genotype

Genotype
MGI:2450141

• Allelic Composition: Tg(KRT14-Pgf)1Odo/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:77722 )

• number of and the diameters of small blood vessels are increased in the upper dermis

abnormal blood vessel endothelium morphology ( J:77722 )

• presence of multiple fenestrations and gaps in the skin endothelium resulting in increased vascular permeability

abnormal angiogenesis ( J:77722 )

• increase in dermal vascularization with age, associated with active neoangiogenesis

abnormal vascular branching morphogenesis ( J:77722 )

• increased vessel branching

increased vascular permeability ( J:77722 )

integument

reddish skin ( J:77722 )

• skin of neonates have swollen and red appearance

• this phenotype persists into adulthood and intensity increases with age