Phenotypes Associated with This Genotype

Genotype
MGI:2446654

• Allelic Composition: Dcc^kanga/Dcc^kanga
• Genetic Background: involves: AKR * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:80430 )

• mild to severe inability to remain upright

abnormal gait ( J:80430 )

• hopping-like gait

nervous system

abnormal axon guidance ( J:80430 )

• some axons fail to cross the midline at the pyramidal decussation and instead extend into the ipsilateral lateral funiculus but not into the ventral funiculus

absent corpus callosum ( J:80430 )

absent hippocampal commissure ( J:80430 )

• absent hippocampal commissure

abnormal pyramidal decussation morphology ( J:80430 )

• no axons cross the midline at the pyramidal decussation instead axons spread medially to laterally just before the decussation then split into medial and lateral bundles

abnormal pontine nuclei morphology ( J:80430 )

• absence of pontine nuclei from the hindbrain

abnormal corticospinal tract morphology ( J:80430 )

• absent from the dorsal funiculus

• no axons cross the midline at the pyramidal decussation instead axons spread medially to laterally just before the decussation then split into medial and lateral bundles

• the abnormal medial bundle extends ipsilaterally into the ventral regions of the ipsilateral lateral funiculus

cellular

abnormal axon guidance ( J:80430 )

• some axons fail to cross the midline at the pyramidal decussation and instead extend into the ipsilateral lateral funiculus but not into the ventral funiculus