Phenotypes Associated with This Genotype

Genotype
MGI:2386979

• Allelic Composition: Twist1^tm1Bhr/Twist1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

enlarged interparietal bone ( J:44379 )

• overdeveloped; 10% larger and 20% longer, on average

limbs/digits/tail

polydactyly ( J:44379 )

• extra digits found on hindlimbs; usually affecting metatarsus and three phlanges

skeleton

enlarged interparietal bone ( J:44379 )

• overdeveloped; 10% larger and 20% longer, on average

premature coronal suture closure ( J:198060 )

• mice show variable coronal synostosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Saethre-Chotzen syndrome		DOID:14768	OMIM:101400 OMIM:180750	J:44379