Phenotypes Associated with This Genotype

Genotype
MGI:2386978

• Allelic Composition: Twist1^tm1Bhr/Twist1^tm1Bhr
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:24349 )

• die by E11.5

nervous system

open neural tube ( J:24349 )

• often accompanied by cranial neural fold hemorrhages; caudal region open, but trunk region often closed

exencephaly ( J:24349 )

• neural tube open from anterior extremity to rhombemere 4

embryo

open neural tube ( J:24349 )

• often accompanied by cranial neural fold hemorrhages; caudal region open, but trunk region often closed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Saethre-Chotzen syndrome		DOID:14768	OMIM:101400 OMIM:180750	J:44379