Phenotypes Associated with This Genotype

Genotype
MGI:2385751

• Allelic Composition: Tg(UcpDta)1Kz/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:78211 )

• by 27 weeks, mice were nearly double the weight of controls

obese ( J:78211 )

• evident at 16 days of age and progressive

adipose tissue

decreased brown adipose tissue amount ( J:78211 )

• lacked brown adipose tissue

increased percent body fat/body weight ( J:78211 )

• by 19 weeks, mice had greater than 50% body fat

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:78211 )

N • normal corticosterone levels

abnormal glucose homeostasis ( J:78211 )

hyperglycemia ( J:78211 )

increased circulating insulin level ( J:78211 )

• hyperinsulinemia

insulin resistance ( J:78211 )

abnormal lipid homeostasis ( J:78211 )

increased circulating cholesterol level ( J:78211 )

• hypercholesterolemia

increased circulating triglyceride level ( J:78211 , J:147417 )

• hypertriglyceridemia (J:78211)

• plasma triglyceride is dramatically increased over that of non-transgenic controls, and this can be reduced by hepatic overexpression of lipin 1 (J:147417)

hyperlipidemia ( J:78211 )

behavior/neurological

polyphagia ( J:78211 )

• beginning at 5-7 weeks

nervous system

nervous system phenotype ( J:78211 )

N • histologically normal hypothalamus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:78211