Phenotypes Associated with This Genotype

Genotype
MGI:2178044

hm1

• Allelic Composition: Krt8^tm1Rgo/Krt8^tm1Rgo
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:121811 , J:12899 )

• tetraploid rescue of embryonic lethality (J:121811)

• normal survival through E9.5 (J:12899)

• dramatically reduced survival between E12 and E13 (J:12899)

• Background Sensitivity: small proportion of homozygotes (6%) survive to adulthood on this background (J:12899)

embryo

decreased embryo weight ( J:12899 )

• 65-70% of normal weight by E12.5

abnormal placenta morphology ( J:121811 )

• partially coagulated blood accumulates between the decidua and the yolk sac

abnormal trophoblast layer morphology ( J:121811 )

• disruption of the trophoblast giant cell layer

abnormal trophoblast giant cell morphology ( J:121811 )

• degeneration of trophoblast giant cells

abnormal extraembryonic tissue physiology ( J:121811 )

• massive hemorrhage of maternal blood between the deciduas capsularis and the parietal yolk sac

impaired placental function ( J:121811 )

cardiovascular system

internal hemorrhage ( J:12899 )

• internal bleeding observed in some embryos

hematopoietic system

extramedullary hematopoiesis ( J:12899 )

• abnormal accumulations of nucleated embryonic erythrocytes in the liver at E12.5

reproductive system

reduced female fertility ( J:12899 )

♀ • Background Sensitivity: reduced female fertility

growth/size/body

decreased embryo weight ( J:12899 )

• 65-70% of normal weight by E12.5