Phenotypes Associated with This Genotype

Genotype
MGI:2175073

• Allelic Composition: Iac/Iac⁺
• Genetic Background: involves: 101 * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:6686 )

• higher mortality

growth/size/body

abnormal tooth morphology ( J:6686 , J:9528 )

• long teeth (J:6686)

• long teeth (J:9528)

decreased body size ( J:6686 )

vision/eye

abnormal pupillary reflex ( J:6686 )

• pupillary reaction is minimal or absent

abnormal placement of pupils ( J:9528 )

irregularly shaped pupil ( J:6686 )

• shape of the pupil varies from oval to slit-like

cataract ( J:6686 , J:9528 )

• cortical or total opacity; bilateral (J:6686)

coloboma ( J:6686 , J:9528 )

• atypical colobomata often present (J:6686)

microphthalmia ( J:9528 )

craniofacial

abnormal cranium morphology ( J:6686 )

• twisted skull resulting from long teeth

abnormal tooth morphology ( J:6686 , J:9528 )

• long teeth (J:6686)

• long teeth (J:9528)

skeleton

abnormal cranium morphology ( J:6686 )

• twisted skull resulting from long teeth

abnormal tooth morphology ( J:6686 , J:9528 )

• long teeth (J:6686)

• long teeth (J:9528)

behavior/neurological

abnormal pupillary reflex ( J:6686 )

• pupillary reaction is minimal or absent

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:9528