Phenotypes Associated with This Genotype

Genotype
MGI:2174880

tg2

• Allelic Composition: Tg(KRT14-PTHLH)7Wmp/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased subcutaneous adipose tissue amount ( J:65043 )

• very little fat is present in the subcutis

integument

decreased subcutaneous adipose tissue amount ( J:65043 )

• very little fat is present in the subcutis

abnormal auchene hair morphology ( J:65043 )

• the relative frequency of the auchene hairs is reduced

abnormal awl hair morphology ( J:65043 )

• the relative frequency of the awl hairs is reduced

abnormal hair growth ( J:65043 )

focal ventral hair loss ( J:65043 )

• by 6 days of age, mutants exhibit ventral hairlessness that extends the length of the body and to the midaxillary lines bilaterally

• males are less severely affected and show some ventral hair growth in two paramedial strips

short hair ( J:65043 )

• all hair types are present but are shorter

sparse hair ( J:65043 )

• dorsal coat is thinner and is deficient in overhairs, the long hairs that protrude beyond the general coat

thin hair shaft ( J:65043 )

• all hair types are present but are thinner

abnormal hair follicle morphology ( J:65043 )

• hair follicles are almost completely absent in the ventral skin

abnormal hair follicle development ( J:65043 )

• fail to initiate follicle development in the ventral skin, leading to absence of hair follicles

• show a delay in the initiation of hair follicles and eruption of hair on the dorsal skin

decreased hair follicle number ( J:65043 )

• a somewhat lower density of hair follicles occurs dorsally, with a selective decrease in the larger and more deeply penetrating follicles

abnormal dermal layer morphology ( J:65043 )

• the ventral dermis is expanded

hyperkeratosis ( J:65043 )

• mild hyperkeratosis in the ventral epidermis and ear epidermis

thick epidermis ( J:65043 )

• the ventral epidermis and the epidermis of the ear are thickened

abnormal tail ring morphology ( J:65043 )

• tail skin shows an effacement of the alternating ridge-like epidermal pattern

thin skin ( J:65043 )

• overall thickness of the skin is reduced due to the decreased amount of fat in the subcutis