Phenotypes Associated with This Genotype

Genotype
MGI:2167813

• Allelic Composition: Hoxa4^tm1Bhr/Hoxa4^tm1Bhr
• Genetic Background: either: 129S/SvEv-Hoxa4^tm1Bhr or (involves: 129S7/SvEvBrd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Homeotic transformation of C3 in Hoxa4^tm1Bhr/Hoxa4^tm1Bhr mice

skeleton

sternebra fusion ( J:22077 )

• 33% with 1-2 fused sternebrae

asymmetric rib joints ( J:22077 )

increased rib number ( J:22077 )

• 48% develop an extensive rib on the 7th cervical vertebra (C7), of these 20% are long enough to fuse to the costal cartilage of the T1 rib

cervical vertebral transformation ( J:22077 )

• extensive ribs on C7 in 48% of homozygotes

• processus spinus normally associated with C2 is also found on C3 in 71% of homozygotes

abnormal sternum ossification ( J:22077 )

• rarely, asymetrical ossification