Phenotypes Associated with This Genotype

Genotype
MGI:2166814

• Allelic Composition: Gsc^tm1Pgr/Gsc^tm1Pgr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:29421 )

• mice die within 24 hours of birth with no milk in their stomachs

craniofacial

abnormal Meckel's cartilage morphology ( J:29421 )

• with aberrant muscle connections

small alisphenoid bone ( J:29421 )

• reduced and malformed

small pterygoid bone ( J:29421 )

• reduced and malformed

absent ethmoturbinates ( J:29421 )

abnormal mandible morphology ( J:29421 )

• the coronoid and angular processes are reduced

• however, the condilar process is normal

• mice exhibit a novel groove in the lower mandible along Meckel's cartilage unlike in wild-type mice

abnormal mandibular angle morphology ( J:29421 )

• the mandible angular processes are reduced

small mandibular coronoid process ( J:29421 )

• the coronoid processes are reduced

mandible hypoplasia ( J:29421 )

abnormal palatine bone morphology ( J:29421 )

palatine bone hypoplasia ( J:29421 )

• reduced and malformed

abnormal vomer bone morphology ( J:29421 )

• reduced and malformed

small vomer bone ( J:29421 )

small malleus manubrium ( J:29421 )

absent malleus processus brevis ( J:29421 )

abnormal nasal capsule morphology ( J:29421 )

abnormal masticatory muscle morphology ( J:29421 )

• jaw muscles, including the genioglosssus, geniohyoid, hypoglossus, mylohoid, and masseter muscles, exhibit underdeveloped alignment with disturbed cellular arrangements unlike in wild-type mice

abnormal intrinsic tongue muscle morphology ( J:29421 )

• the alignment of the anterior intrinsic tongue muscles is confused compared to in wild-type mice

abnormal nasal cavity morphology ( J:29421 )

abnormal nasal septum morphology ( J:29421 )

• the nasal septum fails to fuse with the secondary palate

• however, the secondary palate is normal

abnormal horizontal basal cell of olfactory epithelium morphology ( J:29421 )

• basal cell layers are aplastic

absent external auditory canal ( J:59750 , J:29421 )

hearing/vestibular/ear

small malleus manubrium ( J:29421 )

absent malleus processus brevis ( J:29421 )

absent external auditory canal ( J:59750 , J:29421 )

abnormal epitympanic recess morphology ( J:59750 )

• the epitympanic recess is not as clear as in wild-type mice

abnormal tympanic membrane morphology ( J:29421 )

absent tympanic membrane ( J:59750 )

absent tympanic ring ( J:29421 )

decreased tympanic ring size ( J:59750 )

• the tympanic bone is reduced and does not form the typical annular shape as in wild-type mice

muscle

abnormal masticatory muscle morphology ( J:29421 )

• jaw muscles, including the genioglosssus, geniohyoid, hypoglossus, mylohoid, and masseter muscles, exhibit underdeveloped alignment with disturbed cellular arrangements unlike in wild-type mice

abnormal intrinsic tongue muscle morphology ( J:29421 )

• the alignment of the anterior intrinsic tongue muscles is confused compared to in wild-type mice

growth/size/body

absent ethmoturbinates ( J:29421 )

palatine bone hypoplasia ( J:29421 )

• reduced and malformed

abnormal nasal capsule morphology ( J:29421 )

abnormal masticatory muscle morphology ( J:29421 )

• jaw muscles, including the genioglosssus, geniohyoid, hypoglossus, mylohoid, and masseter muscles, exhibit underdeveloped alignment with disturbed cellular arrangements unlike in wild-type mice

abnormal intrinsic tongue muscle morphology ( J:29421 )

• the alignment of the anterior intrinsic tongue muscles is confused compared to in wild-type mice

abnormal nasal cavity morphology ( J:29421 )

abnormal nasal septum morphology ( J:29421 )

• the nasal septum fails to fuse with the secondary palate

• however, the secondary palate is normal

abnormal horizontal basal cell of olfactory epithelium morphology ( J:29421 )

• basal cell layers are aplastic

absent external auditory canal ( J:59750 , J:29421 )

decreased birth body size ( J:29421 )

• mice are small at birth

respiratory system

absent ethmoturbinates ( J:29421 )

abnormal nasal capsule morphology ( J:29421 )

abnormal nasal cavity morphology ( J:29421 )

abnormal nasal septum morphology ( J:29421 )

• the nasal septum fails to fuse with the secondary palate

• however, the secondary palate is normal

abnormal horizontal basal cell of olfactory epithelium morphology ( J:29421 )

• basal cell layers are aplastic

skeleton

abnormal Meckel's cartilage morphology ( J:29421 )

• with aberrant muscle connections

small alisphenoid bone ( J:29421 )

• reduced and malformed

small pterygoid bone ( J:29421 )

• reduced and malformed

absent ethmoturbinates ( J:29421 )

abnormal mandible morphology ( J:29421 )

• the coronoid and angular processes are reduced

• however, the condilar process is normal

• mice exhibit a novel groove in the lower mandible along Meckel's cartilage unlike in wild-type mice

abnormal mandibular angle morphology ( J:29421 )

• the mandible angular processes are reduced

small mandibular coronoid process ( J:29421 )

• the coronoid processes are reduced

mandible hypoplasia ( J:29421 )

abnormal palatine bone morphology ( J:29421 )

palatine bone hypoplasia ( J:29421 )

• reduced and malformed

abnormal vomer bone morphology ( J:29421 )

• reduced and malformed

small vomer bone ( J:29421 )

small malleus manubrium ( J:29421 )

absent malleus processus brevis ( J:29421 )

abnormal nasal capsule morphology ( J:29421 )

taste/olfaction

abnormal horizontal basal cell of olfactory epithelium morphology ( J:29421 )

• basal cell layers are aplastic

behavior/neurological

absent gastric milk in neonates ( J:29421 )

digestive/alimentary system

palatine bone hypoplasia ( J:29421 )

• reduced and malformed

abnormal intrinsic tongue muscle morphology ( J:29421 )

• the alignment of the anterior intrinsic tongue muscles is confused compared to in wild-type mice