Phenotypes associated with this allele

• Allele Symbol: C3^tm1.2Ozg
• Allele Name: targeted mutation 1.2, Ozgene
• Allele ID: MGI:8460701
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C3^tm1.2Ozg/C3^tm1.2Ozg	involves: C57BL/6	MGI:8460756

Genotype
MGI:8460756

hm1

• Allelic Composition: C3^tm1.2Ozg/C3^tm1.2Ozg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

kidney microaneurysm ( J:295266 )

• in glomeruli at age 14-28 days

embryo

embryo phenotype ( J:295266 )

N • mice born at expected Mendelian ratios

growth/size/body

slow postnatal weight gain ( J:295266 )

• lower weight at weaning age (P18-21)

homeostasis/metabolism

increased urine creatinine level ( J:295266 )

abnormal thrombosis ( J:295266 )

• thrombotic microangiopathy (TMA) in glomeruli

increased urine protein level ( J:295266 )

hematuria ( J:295266 )

immune system

abnormal complement pathway ( J:295266 )

• higher plasma factor H (FH) levels

• lower plasma C5 levels

• C9 deposits in glomeruli

mortality/aging

premature death ( J:295266 )

• increased mortality from age P50

renal/urinary system

kidney microaneurysm ( J:295266 )

• in glomeruli at age 14-28 days

increased urine creatinine level ( J:295266 )

increased urine protein level ( J:295266 )

hematuria ( J:295266 )

mesangiolysis ( J:295266 )

• in glomeruli at age 14-28 days

renal glomerular C3 deposits ( J:295266 )

renal glomerulus fibrosis ( J:295266 )

• at age 14-28 days

kidney failure ( J:295266 )

• end-stage renal failure in some mice