Phenotypes associated with this allele

• Allele Symbol: Jak3^tm1.1Sebma
• Allele Name: targeted mutation 1.1, Sebastien Malinge
• Allele ID: MGI:8436606
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jak3^tm1.1Sebma/Jak3^tm1.1Sebma	B6.129S6(SJL)-Jak3^tm1.1Sebma	MGI:8436627

Genotype
MGI:8436627

hm1

• Allelic Composition: Jak3^tm1.1Sebma/Jak3^tm1.1Sebma
• Genetic Background: B6.129S6(SJL)-Jak3^tm1.1Sebma

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:290824 )

N • mice born at expected Mendelian ratios

hematopoietic system

increased leukocyte cell number ( J:290824 )

• at age 6-8 months

increased single-positive T cell number ( J:290824 )

• increased CD8+ cell number in spleen starting from age 4-8 months

abnormal splenocyte morphology ( J:290824 )

• enlarged and devoid of structure at age 6-14 months

• increased number of CD3+ cells at age 10 months

increased splenocyte number ( J:290824 )

• at age 6-8 months

immune system

increased leukocyte cell number ( J:290824 )

• at age 6-8 months

increased single-positive T cell number ( J:290824 )

• increased CD8+ cell number in spleen starting from age 4-8 months

abnormal splenocyte morphology ( J:290824 )

• enlarged and devoid of structure at age 6-14 months

• increased number of CD3+ cells at age 10 months

increased splenocyte number ( J:290824 )

• at age 6-8 months

lymph node hyperplasia ( J:290824 )

• at age 6-8 months