Phenotypes associated with this allele

• Allele Symbol: Dnm1l^tm1.1Dnsh
• Allele Name: targeted mutation 1.1, Farhad R Danesh
• Allele ID: MGI:8434888
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnm1l^tm1.1Dnsh/Dnm1l^tm1.1Dnsh	involves: C57BL/6	MGI:8434912
cx2	Dnm1l^tm1.1Dnsh/Dnm1l^tm1.1Dnsh Dock7^m/Dock7^m Lepr^db/Lepr^db	involves: C57BL/6 * C57BLKS/J	MGI:8434907

Genotype
MGI:8434912

hm1

• Allelic Composition: Dnm1l^tm1.1Dnsh/Dnm1l^tm1.1Dnsh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:289688 )

N • normal mitochondrial fission in podocytes

embryo

embryo phenotype ( J:289688 )

N • mice born at expected Mendelian ratios

growth/size/body

growth/size/body region phenotype ( J:289688 )

N • normal body weight

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:289688 )

N • normal blood glucose and urine albumin levels

mortality/aging

mortality/aging ( J:289688 )

N • viable

reproductive system

reproductive system phenotype ( J:289688 )

N • fertile

Genotype
MGI:8434907

cx2

• Allelic Composition: Dnm1l^tm1.1Dnsh/Dnm1l^tm1.1Dnsh; Dock7^m/Dock7^m; Lepr^db/Lepr^db
• Genetic Background: involves: C57BL/6 * C57BLKS/J

cellular

decreased mitochondrial fission ( J:289688 )

• in podocytes compared to diabetic controls

embryo

embryo phenotype ( J:289688 )

N • mice born at expected Mendelian ratios

growth/size/body

growth/size/body region phenotype ( J:289688 )

N • normal body weight compared to diabetic controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:289688 )

N • normal blood glucose and serum creatinine levels compared to diabetic controls

decreased urine albumin level ( J:289688 )

• at age 20 weeks compared to diabetic controls

mortality/aging

mortality/aging ( J:289688 )

N • viable

renal/urinary system

decreased urine albumin level ( J:289688 )

• at age 20 weeks compared to diabetic controls

abnormal podocyte foot process morphology ( J:289688 )

• reduced foot process effacement compared to diabetic controls

increased renal glomerulus basement membrane thickness ( J:289688 )

• compared to diabetic controls

abnormal mesangial matrix morphology ( J:289688 )

• reduced expansion (MME) compared to diabetic controls

reproductive system

reproductive system phenotype ( J:289688 )

N • fertile