Phenotypes associated with this allele

• Allele Symbol: Tmem43^tm1.1Xlin
• Allele Name: targeted mutation 1.1, Xin Lin
• Allele ID: MGI:8434063
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tmem43^tm1.1Xlin/Tmem43^+	involves: 129 * C57BL/6 * FVB/N	MGI:8434302

Genotype
MGI:8434302

ht1

• Allelic Composition: Tmem43^tm1.1Xlin/Tmem43⁺
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal adipose tissue amount ( J:289209 )

• increased fat accumulation in heart

cardiovascular system

cardiovascular system phenotype ( J:289209 )

N • no arrhythmia after intense activity

increased heart weight ( J:289209 )

• increased heart-to-body-weight ratio

increased heart left ventricle size ( J:289209 )

• increased left ventricle end-diastolic dimension (LVEDD)

decreased heart left ventricle posterior wall thickness ( J:289209 )

• decreased posterior wall thickness in systole (PWTS)

cardiac fibrosis ( J:289209 )

cellular

abnormal myofibroblast differentiation ( J:289209 )

• increased number of myofibroblasts in heart with concomitant decrease in number of cardiac fibroblasts

growth/size/body

increased heart weight ( J:289209 )

• increased heart-to-body-weight ratio

immune system

immune system phenotype ( J:289209 )

N • normal inflammatory response