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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mdm4tm2.1Tldo
targeted mutation 2.1, Franck Toledo
MGI:8433202
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mdm4tm2.1Tldo/Mdm4tm2.1Tldo involves: 129S2/SvPas MGI:8433213


Genotype
MGI:8433213
hm1
Allelic
Composition		 Mdm4tm2.1Tldo/Mdm4tm2.1Tldo
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm2.1Tldo mutation (0 available); any Mdm4 mutation (192 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular

mortality/aging
perinatal lethality, complete penetrance ( J:288784 )
• mice die within 30 minutes of birth from neonatal respiratory failure

respiratory system
respiratory failure ( J:288784 )
• newborn pups fail to breathe




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory