Phenotypes associated with this allele

• Allele Symbol: Prkdc^tm5.1Shzh
• Allele Name: targeted mutation 5.1, Shan Zha
• Allele ID: MGI:8422512
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkdc^tm5.1Shzh/Prkdc^tm5.1Shzh	involves: 129	MGI:8422567

Genotype
MGI:8422567

hm1

• Allelic Composition: Prkdc^tm5.1Shzh/Prkdc^tm5.1Shzh
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal ribosome biogenesis ( J:287062 )

• impaired pre-rRNA processing and small subunit assembly

impaired translation ( J:287062 )

embryo

abnormal embryo morphology ( J:287062 )

• pale organs

hematopoietic system

macrocytic anemia ( J:287062 )

• in embryos

decreased bone marrow cell number ( J:287062 )

• vacuolization of bone marrow

thrombocytopenia ( J:287062 )

• in embryos

decreased hematopoietic stem cell number ( J:287062 )

• 1000x decrease

homeostasis/metabolism

impaired translation ( J:287062 )

mortality/aging

postnatal lethality, complete penetrance ( J:287062 )

• ~95% mortality by age 4 weeks; no survival beyond age ~52 days