Phenotypes associated with this allele

• Allele Symbol: Scn1a^em1Maag
• Allele Name: endonuclease-mediated mutation 1, Arn M J M van den Maagdenberg
• Allele ID: MGI:8409631
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn1a^em1Maag/Scn1a^em1Maag	C57BL/6-Scn1a^em1Maag	MGI:8409640

Genotype
MGI:8409640

hm1

• Allelic Composition: Scn1a^em1Maag/Scn1a^em1Maag
• Genetic Background: C57BL/6-Scn1a^em1Maag

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:285436 )

N • no seizures prior to death

mortality/aging

premature death ( J:285436 )

• peak mortality between ages P21-35

postnatal lethality ( J:285436 )

• peak mortality between ages P21-35

nervous system

abnormal action potential ( J:285436 )

• cortical spreading depolarization (CSD) propagating from primary visual to primary motor cortex