Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sorem3.1(CAG-MTRFR)Rwb endonuclease-mediated mutation 3.1, Robert W Burgess MGI:8407860 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Male and female body weights, optic nerves, sciatic nerves, motor and sensory branches of the femoral nerves, spinal cord, heart, liver, kidney, spleen, medial gastrocnemius, eye, and brain were all found to be normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• This transgenic expression of wildtype human MTRFR partially rescues the embryonic lethality caused by homozygosity of the K155* mutation in that some homozygotes were born although less than half the number expected from a full rescue. Surviving homozygotes were found to be normal in all assessments including body weight, wire hang duration, sciatic nerve conduction velocity, peripheral nerve histology, retina, optic nerve, ratio of triceps surae weight to body weight, and no biomarker indication of integrated stress response.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/15/2026 MGI 6.29 |
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