About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trip12em1Gno
endonuclease-mediated mutation 1, Gaia Novarino
MGI:8395600
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Trip12em1Gno/Trip12+ C57BL/6J-Trip12em1Gno MGI:8395616


Genotype
MGI:8395616
ht1
Allelic
Composition		 Trip12em1Gno/Trip12+
Genetic
Background		 C57BL/6J-Trip12em1Gno
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trip12em1Gno mutation (0 available); any Trip12 mutation (168 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal action potential ( J:389441 )
• small, but significant, excitation-inhibition frequency imbalance is seen in layer II/III somatosensory cortical pyramidal neurons at P7
• however, mice exhibit no obvious differences in passive or active membrane properties in layer II/III somatosensory cortical pyramidal neurons at P7
decreased miniature excitatory postsynaptic current frequency ( J:389441 )
• mEPSC frequency is reduced in layer II/III somatosensory cortical pyramidal neurons at P7




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
07/08/2026
MGI 6.24 		The Jackson Laboratory