All Phenotypes Isl1<tm1Limli> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Isl1^tm1Limli
targeted mutation 1, Limei Liu
MGI:8375859

Summary

2 genotypes

Allelic Composition	Isl1^tm1Limli/Isl1^tm1Limli
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1Limli mutation (0 available); any Isl1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased insulin secretion ( J:387563 )

• in intraperitoneal glucose tolerance test (IPGTT) at age 16 weeks

homeostasis/metabolism

decreased insulin secretion ( J:387563 )

• in intraperitoneal glucose tolerance test (IPGTT) at age 16 weeks

• in intraperitoneal glucose tolerance test (IPGTT), increasing from age 8 weeks to 16 weeks

hyperglycemia ( J:387563 )

• in intraperitoneal glucose tolerance test (IPGTT), increasing from age 8 weeks to 16 weeks

insulin resistance ( J:387563 )

• in intraperitoneal insulin tolerance test (IPITT) at age 18 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:387563

Allelic Composition	Isl1^tm1Limli/Isl1⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1Limli mutation (0 available); any Isl1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased insulin secretion ( J:387563 )

• in intraperitoneal glucose tolerance test (IPGTT) at age 16 weeks

homeostasis/metabolism

decreased insulin secretion ( J:387563 )

• in intraperitoneal glucose tolerance test (IPGTT) at age 16 weeks

• in intraperitoneal glucose tolerance test (IPGTT), increasing from age 8 weeks to 16 weeks

hyperglycemia ( J:387563 )

• in intraperitoneal glucose tolerance test (IPGTT), increasing from age 8 weeks to 16 weeks

insulin resistance ( J:387563 )

• in intraperitoneal insulin tolerance test (IPITT) at age 18 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:387563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/09/2026 MGI 6.24