Phenotypes associated with this allele

• Allele Symbol: Med13l^{tm1d(KOMP)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:8351551
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Med13l^tm1d(KOMP)Wtsi/Med13l^+	involves: C57BL/6N	MGI:8351552

Genotype
MGI:8351552

ht1

• Allelic Composition: Med13l^{tm1d(KOMP)Wtsi}/Med13l⁺
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal squamoparietal suture morphology ( J:376345 )

• a subset of mice display unilateral discontinuations in the squamosal suture, irrespective of laterality and the presence of the crooked snout

malocclusion ( J:376345 )

• malocclusion occurs in mice with a crooked snout

• however, mandible defects are not seen

abnormal midface morphology ( J:376345 )

• approximately 61% of mice display anomalies of the midfacial elements which are not visible until approximately weaning age

abnormal snout morphology ( J:376345 )

• approximately 22% of mice exhibit a pug snout with midface hypoplasia

• approximately 39% of mice exhibit a crooked snout that results in malocclusion

growth/size/body

malocclusion ( J:376345 )

• malocclusion occurs in mice with a crooked snout

• however, mandible defects are not seen

abnormal midface morphology ( J:376345 )

• approximately 61% of mice display anomalies of the midfacial elements which are not visible until approximately weaning age

abnormal snout morphology ( J:376345 )

• approximately 22% of mice exhibit a pug snout with midface hypoplasia

• approximately 39% of mice exhibit a crooked snout that results in malocclusion

decreased body size ( J:376345 )

• mice show physical developmental delay such that mice are smaller at P7 but follow the same growth curve and rate of growth as wild-type mice over the next 7 weeks and never make up for the initial size difference at P7

skeleton

abnormal squamoparietal suture morphology ( J:376345 )

• a subset of mice display unilateral discontinuations in the squamosal suture, irrespective of laterality and the presence of the crooked snout

malocclusion ( J:376345 )

• malocclusion occurs in mice with a crooked snout

• however, mandible defects are not seen

cardiovascular system

cardiovascular system phenotype ( J:376345 )

N • 4-month-old mice do not exhibit any differences in heart rate, ejection fraction, end-diastolic volume, or end-systolic volume and no differences at 12 months are seen on echocardiograms