Phenotypes associated with this allele

• Allele Symbol: Dctn1^tm1.1Ytsu
• Allele Name: targeted mutation 1.1, Yoshio Tsuboi
• Allele ID: MGI:8347489
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dctn1^tm1.1Ytsu/Dctn1^tm1.1Ytsu	involves: C57BL/6 * C57BL/6NJcl * CBA * Swiss Webster	MGI:8353812
ht2	Dctn1^tm1.1Ytsu/Dctn1^+	involves: C57BL/6 * C57BL/6NJcl * CBA * Swiss Webster	MGI:8353813

Genotype
MGI:8353812

hm1

• Allelic Composition: Dctn1^tm1.1Ytsu/Dctn1^tm1.1Ytsu
• Genetic Background: involves: C57BL/6 * C57BL/6NJcl * CBA * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:375720 )

• only 2 homozygotes are obtained from heterozygote intercrossing, indicating embryonic or neonatal lethality

Genotype
MGI:8353813

ht2

• Allelic Composition: Dctn1^tm1.1Ytsu/Dctn1⁺
• Genetic Background: involves: C57BL/6 * C57BL/6NJcl * CBA * Swiss Webster

behavior/neurological

behavioral despair ( J:375720 )

• in the tail suspension test, 6- and 9-month-old males and 15-month-old females show longer periods of immobility indicating depression-like behavior

• however, mice show no deficit in exploratory behavior in the open-field indicating no apathy-like behavior

impaired coordination ( J:375720 )

♀ • in the beam walking test, females at 9 months, but not 6 months, show an increase in traversing time of beam

♀ • however, male mice show no difference in traversing the beam and mice of both sexes and all ages show no difference in latency to fall on the rotarod

bradykinesia ( J:375720 )

♀ • 9-month-old females take longer to perform a turn (t-turn) or a descent (t-descent) in the pole test and 15-month-old females show a longer t-descent, indicative of parkinsonian bradykinesia

♀ • however, 9-month-old males only show a tendency of extended t-turn

♀ • heavier body weight of males compared to females may suggest that this heavier weight prevents detection of motor dysfunction in males as correlation between body weight and reduction in motor performance are detected

nervous system

decreased dopaminergic neuron number ( J:375720 )

♂ • males, but not females, exhibit reduced tyrosine hydroxylase signal intensity in cell bodies in the substantia nigra pars compacta and neurites in the substantia nigra reticulum, indicating a reduction of catecholaminergic, including dopaminergic neurons in the substantia nigra

growth/size/body

growth/size/body region phenotype ( J:375720 )

N • mice do not exhibit weight loss

muscle

muscle phenotype ( J:375720 )

N • mice show no differences in the traction-meter test indicating normal muscle strength and suggesting no obvious muscle atrophy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Perry syndrome		DOID:0060486	OMIM:168605	J:375720