Analysis Tools
nervous system
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• mice begin to show increased activation of astrocytes at 24 months of age in the cerebral cortex and hippocampus
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• mice begin to show increased activation of microglia at 12 months of age in the cerebral cortex and hippocampus
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• mice exhibit a decrease in mature neurons in the hippocampal CA1 region at 24 months, but not 18 months of age
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• mice show tangle-like inclusions in the hippocampal CA1 region and the retrosplenial region of the cerebral cortex at 24, but not 18, months of age
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• levels of synaptic density in the hippocampal CA3 region begin to decrease at 6 months of age in the (pcl)/striatum lucidum 1 (sl1) area and at 24 months of age in the larger pcl/sl1/stratum lucidum 2 (sl2) area indicating that synapse loss begins from areas closer to the pcl
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cellular
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• mice begin to show increased activation of astrocytes at 24 months of age in the cerebral cortex and hippocampus
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• mice begin to show increased activation of microglia at 12 months of age in the cerebral cortex and hippocampus
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hematopoietic system
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• mice begin to show increased activation of microglia at 12 months of age in the cerebral cortex and hippocampus
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immune system
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• mice begin to show increased activation of microglia at 12 months of age in the cerebral cortex and hippocampus
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| frontotemporal dementia 1 | DOID:0051060 |
OMIM:600274 |
J:197417 | |
