Analysis Tools
nervous system
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• mice begin to show increased activation of astrocytes at 24 months of age in the cerebral cortex and hippocampus
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• mice begin to show increased activation of microglia at 12 months of age in the cerebral cortex and hippocampus
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• mice exhibit a decrease in mature neurons in the hippocampal CA1 region at 24 months, but not 18 months of age
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• mice show tangle-like inclusions in the hippocampal CA1 region and the retrosplenial region of the cerebral cortex at 24, but not 18, months of age; these are intracellular tau-positive filamentous structures and filaments appear as a mixture of paired helical filament- and straight tubule-like structures
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• levels of synaptic density in the hippocampal CA3 region begin to decrease at 6 months of age in the pyramidal cell layer (pcl)/striatum lucidum 1 (sl1) area and at 24 months of age in the larger pcl/sl1/stratum lucidum 2 (sl2) area indicating that synapse loss begins from areas closer to the pcl
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• analysis of basal synaptic transmission in 6-month-old mice shows lowering of Input/Output performance in the pcl, a nonsignificant tendency of lowering in the sl1, and a somewhat inverse tendency in the more distal area of sl2, suggesting that basal synaptic transmission is impaired in a manner depending on the distance from the pcl
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• high-frequency stimulation of the sl1/2 area does not induce long-term potentiation
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behavior/neurological
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• mice at 6, but not 4, months exhibit impaired memory acquisition in the Morris water maze, with longer escape latencies, and lower memory retention in probe trials with platform removal at day 5
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cellular
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• mice begin to show increased activation of astrocytes at 24 months of age in the cerebral cortex and hippocampus
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• mice begin to show increased activation of microglia at 12 months of age in the cerebral cortex and hippocampus
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hematopoietic system
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• mice begin to show increased activation of microglia at 12 months of age in the cerebral cortex and hippocampus
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immune system
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• mice begin to show increased activation of microglia at 12 months of age in the cerebral cortex and hippocampus
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| frontotemporal dementia 1 | DOID:0051060 |
OMIM:600274 |
J:197417 | |
