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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ascl5em1Port
endonuclease-mediated mutation 1, Thantrira Porntaveetus
MGI:8325758
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ascl5em1Port/Ascl5em1Port C57BL/6N-Ascl5em1Port MGI:8326242
ht2
 		Ascl5em1Port/Ascl5+ C57BL/6N-Ascl5em1Port MGI:8326246


Genotype
MGI:8326242
hm1
Allelic
Composition		 Ascl5em1Port/Ascl5em1Port
Genetic
Background		 C57BL/6N-Ascl5em1Port
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl5em1Port mutation (0 available); any Ascl5 mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal molar cusp morphology ( J:382307 )
• no cusp pattern; resemble single-cusped teeth
decreased molar number ( J:382307 )
• maxillary M3 and mandibular M1, M2 and M3 absent
small molars ( J:382307 )
• small maxillary M1 and M2

growth/size/body
abnormal lower incisor morphology ( J:382307 )
• severe wear
abnormal upper incisor morphology ( J:382307 )
• curved
long upper incisors ( J:382307 )
abnormal molar cusp morphology ( J:382307 )
• no cusp pattern; resemble single-cusped teeth
decreased molar number ( J:382307 )
• maxillary M3 and mandibular M1, M2 and M3 absent
small molars ( J:382307 )
• small maxillary M1 and M2
short mandible ( J:382307 )
decreased body size ( J:382307 )
cachexia ( J:382307 )

skeleton
abnormal molar cusp morphology ( J:382307 )
• no cusp pattern; resemble single-cusped teeth
decreased molar number ( J:382307 )
• maxillary M3 and mandibular M1, M2 and M3 absent
small molars ( J:382307 )
• small maxillary M1 and M2




Genotype
MGI:8326246
ht2
Allelic
Composition		 Ascl5em1Port/Ascl5+
Genetic
Background		 C57BL/6N-Ascl5em1Port
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl5em1Port mutation (0 available); any Ascl5 mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
taurodontia ( J:382307 )
• in mandibular M1
abnormal molar cusp morphology ( J:382307 )
• extra cusps on maxillary molars
abnormal molar root morphology ( J:382307 )
• single-rooted mandibular M2
small molars ( J:382307 )
• small mandibular M3

growth/size/body
taurodontia ( J:382307 )
• in mandibular M1
abnormal molar cusp morphology ( J:382307 )
• extra cusps on maxillary molars
abnormal molar root morphology ( J:382307 )
• single-rooted mandibular M2
small molars ( J:382307 )
• small mandibular M3

skeleton
taurodontia ( J:382307 )
• in mandibular M1
abnormal molar cusp morphology ( J:382307 )
• extra cusps on maxillary molars
abnormal molar root morphology ( J:382307 )
• single-rooted mandibular M2
small molars ( J:382307 )
• small mandibular M3




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/12/2026
MGI 6.24 		The Jackson Laboratory