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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nrip1em1Xav
endonuclease-mediated mutation 1, Ramnik J Xavier
MGI:8325262
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nrip1em1Xav/Nrip1em1Xav involves: C57BL/6 MGI:8325274


Genotype
MGI:8325274
hm1
Allelic
Composition		 Nrip1em1Xav/Nrip1em1Xav
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrip1em1Xav mutation (0 available); any Nrip1 mutation (195 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased CD4-positive, alpha-beta T cell number ( J:382768 )
• higher proportion of IFNG+ IL17A+ RORC+ CD4+ in lamina propria (LP) of colon
• normal levels of total FOXP3+ and RORC+ FOXP3+ regulatory T cells

immune system
increased CD4-positive, alpha-beta T cell number ( J:382768 )
• higher proportion of IFNG+ IL17A+ RORC+ CD4+ in lamina propria (LP) of colon
• normal levels of total FOXP3+ and RORC+ FOXP3+ regulatory T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/07/2026
MGI 6.24 		The Jackson Laboratory