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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Snhg5em1Kabo
endonuclease-mediated mutation 1, Karam Aboudehen
MGI:8321888
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Snhg5em1Kabo/Snhg5em1Kabo C57BL/6J-Snhg5em1Kabo MGI:8322160
cn2
 		Snhg5em1Kabo/Snhg5em1Kabo
Pkd1tm2Som/Pkd1tm2Som
Tg(Pkhd1-cre)1Igr/0 		involves: C57BL/6 * C57BL/6J * SJL MGI:8322162


Genotype
MGI:8322160
hm1
Allelic
Composition		 Snhg5em1Kabo/Snhg5em1Kabo
Genetic
Background		 C57BL/6J-Snhg5em1Kabo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snhg5em1Kabo mutation (0 available); any Snhg5 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:379194 )
• mice are born at Mendelian ratios and live a normal lifespan, and exhibit normal kidneys with normal serum creatinine levels




Genotype
MGI:8322162
cn2
Allelic
Composition		 Snhg5em1Kabo/Snhg5em1Kabo
Pkd1tm2Som/Pkd1tm2Som
Tg(Pkhd1-cre)1Igr/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm2Som mutation (0 available); any Pkd1 mutation (154 available)
Snhg5em1Kabo mutation (0 available); any Snhg5 mutation (34 available)
Tg(Pkhd1-cre)1Igr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
polycystic kidney ( J:379194 )
• kidneys exhibit a mild exacerbation of cystic disease seen in single Pkd1 conditional mice, with modestly higher mean kidney weight-to-body weight ratio, cyst index, and cyst counts that do not reach significance
increased kidney weight ( J:379194 )
• kidney weight-to-body-weight ratio is modestly higher than in single Pkd1conditional mutant mice but it does not reach significance

renal/urinary system
polycystic kidney ( J:379194 )
• kidneys exhibit a mild exacerbation of cystic disease seen in single Pkd1 conditional mice, with modestly higher mean kidney weight-to-body weight ratio, cyst index, and cyst counts that do not reach significance
increased kidney weight ( J:379194 )
• kidney weight-to-body-weight ratio is modestly higher than in single Pkd1conditional mutant mice but it does not reach significance




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/07/2026
MGI 6.24 		The Jackson Laboratory