All Phenotypes Wnt2<Tn(pb-Act-RFP)1.091208007-HLAZhu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wnt2^{Tn(pb-Act-RFP)1.091208007-HLAZhu}
transposon insertion 1.091208007-HLA, Yuan Zhuang
MGI:8292637

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt2^{Tn(pb-Act-RFP)1.091208007-HLAZhu}/Wnt2^{Tn(pb-Act-RFP)1.091208007-HLAZhu}	involves: FVB/NJ	MGI:8296713
ht2	Wnt2^{Tn(pb-Act-RFP)1.091208007-HLAZhu}/Wnt2⁺	involves: FVB/NJ	MGI:8296721

Allelic Composition	Wnt2^{Tn(pb-Act-RFP)1.091208007-HLAZhu}/Wnt2^{Tn(pb-Act-RFP)1.091208007-HLAZhu}
Genetic Background	involves: FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt2^{Tn(pb-Act-RFP)1.091208007-HLAZhu} mutation (0 available); any Wnt2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryonic growth retardation ( J:378174 )

• early developmental delay

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:378174 )

• mice are viable at E10.5, E12.5, and E15.5, and subviable at E18.5 and P10

growth/size/body

embryonic growth retardation ( J:378174 )

• early developmental delay

decreased body size ( J:378174 )

cardiovascular system

abnormal cardiovascular development ( J:378174 )

• embryos exhibit cardiovascular defects

abnormal vascular development ( J:378174 )

• vascular system abnormalities

limbs/digits/tail

abnormal limb development ( J:378174 )

• limb abnormalities

liver/biliary system

abnormal liver development ( J:378174 )

• liver abnormalities

vision/eye

abnormal eye development ( J:378174 )

• eye abnormalities

Allelic Composition	Wnt2^{Tn(pb-Act-RFP)1.091208007-HLAZhu}/Wnt2⁺
Genetic Background	involves: FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt2^{Tn(pb-Act-RFP)1.091208007-HLAZhu} mutation (0 available); any Wnt2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:378174 )

• male mice accumulate more fat than wild-type mice

• male mice show increased fat/lean ratio, increased fat mass/body weight ratio, reduced lean mass/body weight ratio, increased fat mass, and no difference in lean mass weight

increased body fat mass ( J:378174 )

growth/size/body

increased body fat mass ( J:378174 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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