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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp73Tn(pb-Act-RFP)1.080925203-HRAZhu
transposon insertion 1.080925203-HRA, Yuan Zhuang
MGI:8292622
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp73Tn(pb-Act-RFP)1.080925203-HRAZhu/Trp73Tn(pb-Act-RFP)1.080925203-HRAZhu involves: C57BL/6 MGI:8296688
ht2
 		Trp73Tn(pb-Act-RFP)1.080925203-HRAZhu/Trp73+ involves: C57BL/6 MGI:8296700


Genotype
MGI:8296688
hm1
Allelic
Composition		 Trp73Tn(pb-Act-RFP)1.080925203-HRAZhu/Trp73Tn(pb-Act-RFP)1.080925203-HRAZhu
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp73Tn(pb-Act-RFP)1.080925203-HRAZhu mutation (0 available); any Trp73 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:378174 )
• mice are viable at E10.5, E12.5, E15.5, and E18.5, and lethal at P10

growth/size/body
prenatal growth retardation ( J:378174 )
• developmental delay




Genotype
MGI:8296700
ht2
Allelic
Composition		 Trp73Tn(pb-Act-RFP)1.080925203-HRAZhu/Trp73+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp73Tn(pb-Act-RFP)1.080925203-HRAZhu mutation (0 available); any Trp73 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
decreased total body fat amount ( J:378174 )
• male mice fail to build up regular levels of adipose tissue and exhibit less fat
• male mice show decreased fat/lean ratio, decreased fat mass/body weight ratio, decreased fat mass, and no difference in lean mass weight
decreased body fat mass ( J:378174 )
• males exhibit decreased fat mass

growth/size/body
decreased body fat mass ( J:378174 )
• males exhibit decreased fat mass




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory