Phenotypes associated with this allele

• Allele Symbol: Scnn1a^{Tn(pb-Act-RFP)1.100121056-HRAZhu}
• Allele Name: transposon insertion 1.100121056-HRA, Yuan Zhuang
• Allele ID: MGI:8292593
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scnn1a^Tn(pb-Act-RFP)1.100121056-HRAZhu/Scnn1a^Tn(pb-Act-RFP)1.100121056-HRAZhu	involves: FVB/NJ	MGI:8296685
ht2	Scnn1a^Tn(pb-Act-RFP)1.100121056-HRAZhu/Scnn1a^+	involves: FVB/NJ	MGI:8296687

Genotype
MGI:8296685

hm1

• Allelic Composition: Scnn1a^{Tn(pb-Act-RFP)1.100121056-HRAZhu}/Scnn1a^{Tn(pb-Act-RFP)1.100121056-HRAZhu}
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:378174 )

• mice are viable at E10.5, E12.5, E15.5, and E18.5, and lethal at P10

growth/size/body

decreased embryo size ( J:378174 )

abnormal body wall morphology ( J:378174 )

• E12.5 embryos exhibit abnormalities in the body wall

decreased body size ( J:378174 )

embryo

decreased embryo size ( J:378174 )

abnormal neural tube morphology ( J:378174 )

• E12.5 embryos exhibit neural tube abnormalities

cardiovascular system

abnormal cardiovascular development ( J:378174 )

• embryos exhibit cardiovascular defects

abnormal vascular development ( J:378174 )

• vascular system abnormalities

liver/biliary system

abnormal liver development ( J:378174 )

• liver abnormalities

nervous system

abnormal neural tube morphology ( J:378174 )

• E12.5 embryos exhibit neural tube abnormalities

Genotype
MGI:8296687

ht2

• Allelic Composition: Scnn1a^{Tn(pb-Act-RFP)1.100121056-HRAZhu}/Scnn1a⁺
• Genetic Background: involves: FVB/NJ

growth/size/body

increased body weight ( J:378174 )

♂ • males at 4 weeks of age are heavier than wild-type mice