Phenotypes associated with this allele

• Allele Symbol: Dyrk1a^{Tn(pb-Act-RFP)1.090903006-HRAZhu}
• Allele Name: transposon insertion 1.090903006-HRA, Yuan Zhuang
• Allele ID: MGI:8292581
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dyrk1a^Tn(pb-Act-RFP)1.090903006-HRAZhu/Dyrk1a^Tn(pb-Act-RFP)1.090903006-HRAZhu	involves: FVB/NJ	MGI:8296546
ht2	Dyrk1a^Tn(pb-Act-RFP)1.090903006-HRAZhu/Dyrk1a^+	involves: FVB/NJ	MGI:8296620

Genotype
MGI:8296546

hm1

• Allelic Composition: Dyrk1a^{Tn(pb-Act-RFP)1.090903006-HRAZhu}/Dyrk1a^{Tn(pb-Act-RFP)1.090903006-HRAZhu}
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development ( J:378174 )

• mice are subviable at E10.5, E12.5, and E15.5, and lethal at E18.5

prenatal lethality prior to heart atrial septation, incomplete penetrance ( J:378174 )

• mice are subviable at E10.5, E12.5, and E15.5

growth/size/body

embryonic growth retardation ( J:378174 )

• early developmental delay

abnormal body size ( J:378174 )

embryo

embryonic growth retardation ( J:378174 )

• early developmental delay

cardiovascular system

abnormal cardiovascular development ( J:378174 )

• embryos exhibit cardiac phenotypes

abnormal vascular development ( J:378174 )

• vascular system abnormalities

liver/biliary system

abnormal liver development ( J:378174 )

• liver abnormalities

Genotype
MGI:8296620

ht2

• Allelic Composition: Dyrk1a^{Tn(pb-Act-RFP)1.090903006-HRAZhu}/Dyrk1a⁺
• Genetic Background: involves: FVB/NJ

growth/size/body

decreased body weight ( J:378174 )

♂ • males at 4 weeks of age are lighter than wild-type mice