Phenotypes associated with this allele

• Allele Symbol: Smad2^{Tn(pb-Act-RFP)1.090901064-HRAZhu}
• Allele Name: transposon insertion 1.090901064-HRA, Yuan Zhuang
• Allele ID: MGI:8292564
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad2^Tn(pb-Act-RFP)1.090901064-HRAZhu/Smad2^Tn(pb-Act-RFP)1.090901064-HRAZhu	involves: FVB/NJ	MGI:8293435
ht2	Smad2^Tn(pb-Act-RFP)1.090901064-HRAZhu/Smad2^+	involves: FVB/NJ	MGI:8293444

Genotype
MGI:8293435

hm1

• Allelic Composition: Smad2^{Tn(pb-Act-RFP)1.090901064-HRAZhu}/Smad2^{Tn(pb-Act-RFP)1.090901064-HRAZhu}
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:378174 )

• mice are viable at E10.5 but exhibit lethality at E12.5

growth/size/body

embryonic growth retardation ( J:378174 )

• early developmental delay

decreased body size ( J:378174 )

embryo

embryonic growth retardation ( J:378174 )

• early developmental delay

cardiovascular system

abnormal cardiovascular development ( J:378174 )

• embryos exhibit cardiac phenotypes

abnormal vascular development ( J:378174 )

• vascular system abnormalities

liver/biliary system

abnormal liver development ( J:378174 )

• liver abnormalities

Genotype
MGI:8293444

ht2

• Allelic Composition: Smad2^{Tn(pb-Act-RFP)1.090901064-HRAZhu}/Smad2⁺
• Genetic Background: involves: FVB/NJ

adipose tissue

decreased total body fat amount ( J:378174 )

♂ • mice show a 17.45% reduction in fat to lean ratio at 4 weeks of age, decreased fat mass/body weight ratio, and increased lean mass/body weight ratio

decreased body fat mass ( J:378174 )

♂

behavior/neurological

behavior/neurological phenotype ( J:378174 )

♂N • locomotor activity is unchanged and no differences in food intake or water intake are seen

growth/size/body

decreased body fat mass ( J:378174 )

♂

decreased body weight ( J:378174 )

♂ • mice show a 16.72% reduction in body weight at 4 weeks of age

♂ • however, body length and skeleton morphology do not show differences

homeostasis/metabolism

increased energy expenditure ( J:378174 )

♂

increased carbon dioxide production ( J:378174 )

♂

increased oxygen consumption ( J:378174 )

♂