Phenotypes associated with this allele

• Allele Symbol: Hmgcr^tm1.1Eihl
• Allele Name: targeted mutation 1.1, Bruce E Kemp
• Allele ID: MGI:8288356
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hmgcr^tm1.1Eihl/Hmgcr^tm1.1Eihl	involves: C57BL/6	MGI:8288379

Genotype
MGI:8288379

hm1

• Allelic Composition: Hmgcr^tm1.1Eihl/Hmgcr^tm1.1Eihl
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:379161 )

N • viable

growth/size/body

growth/size/body region phenotype ( J:379161 )

N • no gross phenotypes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:379161 )

N • normal metabolism when fed chow

increased fasting circulating glucose level ( J:379161 )

• when fed high-carb diet

increased circulating cholesterol level ( J:379161 )

• when fed high-carb diet

increased circulating triglyceride level ( J:379161 )

• when fed high-carb diet

impaired glucose tolerance ( J:379161 )

• when fed high-carb diet

• normal when fed chow

insulin resistance ( J:379161 )

• when fed high-carb diet

• normal when fed chow

increased liver cholesterol level ( J:379161 )

• when fed high-carb diet

increased liver triglyceride level ( J:379161 )

• when fed high-carb diet

immune system

liver inflammation ( J:379161 )

• when fed high-carb diet

liver/biliary system

increased liver cholesterol level ( J:379161 )

• when fed high-carb diet

increased liver triglyceride level ( J:379161 )

• when fed high-carb diet

liver inflammation ( J:379161 )

• when fed high-carb diet

increased susceptibility to diet-induced hepatic steatosis ( J:379161 )

• when fed on high-carb diet

liver fibrosis ( J:379161 )

• when fed high-carb diet

reproductive system

reproductive system phenotype ( J:379161 )

N • fertile