Phenotypes associated with this allele

• Allele Symbol: Card11^tm1.1Pomz
• Allele Name: targeted mutation 1.1, Joel L Pomerantz
• Allele ID: MGI:8286641
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Card11^tm1.1Pomz/Card11^tm1.1Pomz	C57BL/6J-Card11^tm1.1Pomz	MGI:8288319

Genotype
MGI:8288319

hm1

• Allelic Composition: Card11^tm1.1Pomz/Card11^tm1.1Pomz
• Genetic Background: C57BL/6J-Card11^tm1.1Pomz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

enlarged spleen ( J:378638 )

hematopoietic system

hematopoietic system phenotype ( J:378638 )

N • normal numbers of CD4<+> and CD8<+> T cells and NK cells in spleen

N • normal percentages and absolute numbers of Treg cells in thymus

N • normal distribution of B cell developmental stages in bone marrow

enlarged spleen ( J:378638 )

decreased transitional stage T3 B cell number ( J:378638 )

• 55% decrease in percentage of B220<+>CD93<+>CD23<+>IGM B cells in spleen

• normal absolute number of B220<+>CD93<+>CD23<+>IGM B cells in spleen

decreased follicular B cell number ( J:378638 )

• 35% decreased percentage

increased B cell number ( J:378638 )

• 3.5x more in spleen

• 31% increase in CD19<+>B220<+> splenic cells

increased immature B cell number ( J:378638 )

• 2.3x more B220<+>CD93<+> B cells in spleen

increased transitional stage T1 B cell number ( J:378638 )

• 2.5x higher percentage of B220<+>CD93<+>CD23<->IGM B cells in spleen

• 7.5x higher absolute number of B220<+>CD93<+>CD23<->IGM B cells in spleen

increased mature B cell number ( J:378638 )

• 3.6x more B220<+>CD93<-> mature B cells in spleen

increased follicular B cell number ( J:378638 )

• 2.3x more B220<+>CD93<->CD21CD23<+> B cells

increased marginal zone B cell number ( J:378638 )

• 4.1x increased percentage

• 14.1x more B220<+>CD93<->CD21CD23<-> B cells

increased regulatory T cell number ( J:378638 )

• 2.5x more in spleen

increased splenocyte number ( J:378638 )

• 3x more

immune system

enlarged spleen ( J:378638 )

decreased transitional stage T3 B cell number ( J:378638 )

• 55% decrease in percentage of B220<+>CD93<+>CD23<+>IGM B cells in spleen

• normal absolute number of B220<+>CD93<+>CD23<+>IGM B cells in spleen

decreased follicular B cell number ( J:378638 )

• 35% decreased percentage

increased B cell number ( J:378638 )

• 3.5x more in spleen

• 31% increase in CD19<+>B220<+> splenic cells

increased immature B cell number ( J:378638 )

• 2.3x more B220<+>CD93<+> B cells in spleen

increased transitional stage T1 B cell number ( J:378638 )

• 2.5x higher percentage of B220<+>CD93<+>CD23<->IGM B cells in spleen

• 7.5x higher absolute number of B220<+>CD93<+>CD23<->IGM B cells in spleen

increased mature B cell number ( J:378638 )

• 3.6x more B220<+>CD93<-> mature B cells in spleen

increased follicular B cell number ( J:378638 )

• 2.3x more B220<+>CD93<->CD21CD23<+> B cells

increased marginal zone B cell number ( J:378638 )

• 4.1x increased percentage

• 14.1x more B220<+>CD93<->CD21CD23<-> B cells

increased regulatory T cell number ( J:378638 )

• 2.5x more in spleen

increased splenocyte number ( J:378638 )

• 3x more