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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cabin1em2Dcfaj
endonuclease-mediated mutation 2, David C Fajgenbaum
MGI:8286456
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cabin1em2Dcfaj/Cabin1em2Dcfaj C57BL/6J-Cabin1em2Dcfaj MGI:8286545
ht2
 		Cabin1em1Dcfaj/Cabin1em2Dcfaj C57BL/6J-Cabin1em1Dcfaj Cabin1em2Dcfaj MGI:8286547


Genotype
MGI:8286545
hm1
Allelic
Composition		 Cabin1em2Dcfaj/Cabin1em2Dcfaj
Genetic
Background		 C57BL/6J-Cabin1em2Dcfaj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cabin1em2Dcfaj mutation (0 available); any Cabin1 mutation (114 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased spleen germinal center number ( J:378928 )
• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)
decreased spleen germinal center size ( J:378928 )
• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)

homeostasis/metabolism
increased circulating CCL2 level ( J:378928 )
• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong
increased circulating chemokine level ( J:378928 )
• increased CXCL13 and other chemokine and cytokine levels after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong or ovalbumin (OVA-lipid nanoparticles
increased circulating interleukin-6 level ( J:378928 )
• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong

immune system
immune system phenotype ( J:378928 )
N
• normal baseline frequency of B, T and regulatory T cells, and other immune cell populations
decreased spleen germinal center number ( J:378928 )
• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)
decreased spleen germinal center size ( J:378928 )
• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)
increased circulating CCL2 level ( J:378928 )
• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong
increased circulating chemokine level ( J:378928 )
• increased CXCL13 and other chemokine and cytokine levels after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong or ovalbumin (OVA-lipid nanoparticles
increased circulating interleukin-6 level ( J:378928 )
• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong
cytokine storm ( J:378928 )
• after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13) or LCMV Armstrong
increased susceptibility to Riboviria infection induced morbidity/mortality ( J:378928 )
• increased morbidity and mortality after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)

mortality/aging
mortality/aging ( J:378928 )
N
• no spontaneous mortality during 1st year
increased susceptibility to Riboviria infection induced morbidity/mortality ( J:378928 )
• increased morbidity and mortality after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
multicentric Castleman disease DOID:0111152 J:378928




Genotype
MGI:8286547
ht2
Allelic
Composition		 Cabin1em1Dcfaj/Cabin1em2Dcfaj
Genetic
Background		 C57BL/6J-Cabin1em1Dcfaj Cabin1em2Dcfaj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cabin1em1Dcfaj mutation (0 available); any Cabin1 mutation (114 available)
Cabin1em2Dcfaj mutation (0 available); any Cabin1 mutation (114 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:378928 )
N
• normal baseline frequency of B, T and regulatory T cells, and other immune cell populations
increased susceptibility to Riboviria infection induced morbidity/mortality ( J:378928 )
• increased morbidity and mortality after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)

mortality/aging
mortality/aging ( J:378928 )
N
• no spontaneous mortality during 1st year
increased susceptibility to Riboviria infection induced morbidity/mortality ( J:378928 )
• increased morbidity and mortality after infection with lymphocytic choriomeningitis virus clone 13 (LCMV CL13)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
multicentric Castleman disease DOID:0111152 J:378928




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory