Phenotypes associated with this allele

• Allele Symbol: Hmga2^em2Hokl
• Allele Name: endonuclease-mediated mutation 2, Sabine Hombach-Klonisch
• Allele ID: MGI:8282795
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hmga2^em2Hokl/Hmga2^em2Hokl	C57BL/6J-Hmga2^em2Hokl	MGI:8283264
ht2	Hmga2^em2Hokl/Hmga2^+	C57BL/6J-Hmga2^em2Hokl	MGI:8283263

Genotype
MGI:8283264

hm1

• Allelic Composition: Hmga2^em2Hokl/Hmga2^em2Hokl
• Genetic Background: C57BL/6J-Hmga2^em2Hokl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:348065 )

• mice consistently show a pygmy phenotype

decreased body weight ( J:348065 )

reproductive system

infertility ( J:348065 )

• mice are infertile

adipose tissue

abnormal fat cell differentiation ( J:348065 )

• mouse embryonic fibroblasts (MEFs) show diminished adipogenic differentiation, with reduced lipid droplet formation

cellular

abnormal fat cell differentiation ( J:348065 )

• mouse embryonic fibroblasts (MEFs) show diminished adipogenic differentiation, with reduced lipid droplet formation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Silver-Russell syndrome		DOID:14681	OMIM:180860	J:348065

Genotype
MGI:8283263

ht2

• Allelic Composition: Hmga2^em2Hokl/Hmga2⁺
• Genetic Background: C57BL/6J-Hmga2^em2Hokl

growth/size/body

decreased body size ( J:348065 )

• mice show an intermediate growth-restricted phenotype, with lower weights than wild-type mice but higher size than in homozygotes

decreased body weight ( J:348065 )